Want to be able to click on those web+mastodon:// links you sometimes see? Browse to your Mastodon web interface, hit F12, then enter the following into the JavaScript console:
navigator.registerProtocolHandler("web+mastodon", new URL("/intent?uri=%s", document.location.origin), "Mastodon");
Click allow on the banner that pops up.
This used to be built in to the Mastodon UI, but got removed because users found it too confusing (https://github.com/mastodon/mastodon/pull/8127). Let's hope they figure out a way to re-add it, because the current process for following someone on another instance is uncomfortably clunky.